FACULTY
Adam E. Cohen
Assistant Professor of Chemistry and Chemical Biology and of Physics
PhD 2003, Cambridge; PhD 2006, Stanford
Adam Cohen's research focuses on developing and applying
new tools to probe the physical properties of complex
molecules. He invented an Anti-Brownian Electrokinetic
trap (ABEL trap) capable of trapping and manipulating
individual fluorescent molecules in solution at room
temperature. The ABEL trap uses high-speed fluorescence
microscopy to track the Brownian motion of a single
fluorescent molecule. A feedback circuit applies
carefully timed electric fields to the solution to
induce an electrokinetic drift cancels the Brownian
motion.
Current research in the Cohen Lab focuses on application
of the ABEL trap to biomolecular systems, as well as
the development of new tools and method for probing
weak protein-protein interactions and ultrafast dynamics
of molecules inside of cells.
- A.E. Cohen and W. E. Moerner, Principal Components Analysis of shape fluctuations of single DNA molecules, PNAS, 104, 12622-12627 (2007). Journal link and Supporting Material and Movies.
- A.E. Cohen and W. E. Moerner, Internal mechanical response of a polymer in solution, Phys. Rev. Lett., 98, 116001 (2007). Supplementary material.
- A.E. Cohen and W. E. Moerner, Suppressing Brownian motion of individual biomolecules in solution, PNAS, 103, 4362-4365 (14 Mar. 2006). Journal link and Supporting Material and Movies.
- A.E. Cohen and W. E. Moerner, An all-glass microfluidic cell for the ABEL trap: fabrication and modeling, Proc. SPIE 5930 (2005).
- A.E. Cohen, Control of nanoparticles with arbitrary two-dimensional force fields , Phys. Rev. Lett., 94, 118102 ( 2005).
- A.E. Cohen and W. E. Moerner, The Anti-Brownian Electrophoretic trap (ABEL Trap): tabrication and software , Proc. SPIE 5699 (2005).
- S. Mukamel, S., A.E. Cohen, and U. Harbola, Intermolecular forces and generalized TDDFT response functions in Liouville Space, in: M.A.L. Marques, C.A. Ullrich, F. Nogueira, A. Rubio, K. Burke and E.K.U. Gross (eds.), Time-Dependent Density Functional Theory (Springer, 2006).
- A.E. and W. E. Moerner, Method for trapping and manipulating nanoscale objects in solution, Appl. Phys. Lett. 86, 093109 (2005).
- A.E. Cohen and Shaul Mukamel, Resonant enhancement and dissipation in nonequilibrium van der Waals forces , Phys. Rev. Lett. 91 , 233202 (2003).