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X-WR-CALNAME;VALUE=TEXT:Monday Colloquium: David Bensimon (CNRS & UCLA) "Temperature Independence of Somitogenesis and Critical Slowing Down"
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SUMMARY:Monday Colloquium: David Bensimon (CNRS & UCLA) "Temperature Independence of Somitogenesis and Critical Slowing Down"
DESCRIPTION:Somitogenesis, the segmentation of the antero-posterior axis in vertebrates, is thought to result from the interactions between a genetic oscillator and a posterior-moving determination wavefront. The segment (somite) size is set by the product of the oscillator period and the velocity of the determination wavefront. Surprisingly, while the segmentation period can vary by a factor three between 20°C and 31°C, the somite size is constant. How this temperature independence is achieved is a mystery that I will address in my talk. Using RT-qPCR we showed that the endogenous fgf8 mRNA concentration decreases during somitogenesis and correlates with the exponent of the pre-somitic mesoderm (PSM) size. As the temperature decreases, the dynamics of fgf8 and many other gene transcripts, as well as the segmentation frequency and the PSM shortening and tail growth rates slows down as T-Tc (with Tc=14.4°C). This behavior characteristic of a system near a critical point may account for the temperature independence of somitogenesis in zebrafish.
LOCATION:Zoom
STATUS:CONFIRMED
DTSTART:20201116T213000Z
DTEND:20201116T213000Z
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