A New Technique to Make Drugs More Soluble

August 25, 2015

Fig. 3 Operation of the nebulator using a nonwetting fluid*

Amorphous nanoparticles often dissolve more rapidly than their crystalline counterparts, which can be useful in applications such as drug delivery. Professors Michael Brenner and David Weitz, together with colleagues from SEAS, Ecole Polytechnique Fédérale de Lausanne, Yale University, and BASF SE, made amorphous nanoparticles from organic and inorganic compounds—even table salt—using droplets of dissolved compounds created with a microfluidic nebulator. The solvent evaporates fast enough that nanoparticles form before crystal nuclei can develop. The small particle size inhibits crystallization for periods of months

*See E. Amstad, M. Gopinadhan, C. Holtze, C.O. Osuji, M. Brenner, F. Spaepen, and D. Weitz, "Production of amorphous nanoparticles by supersonic spray-drying with a microfluidic nebulator," Science 349:6251 (28 August 2015) DOI: 10.1126/science.aac9582. [Reprinted Reprinted with permission from AAAS © 2015]