3-D Printing Confirms Physical Model of Brain Folds

February 2, 2016

Fig. 1. Physical mimic and numerical simulation of tangential cortical expansion. [Reprinted by permission from Macmillan Publishers Ltd: Nature Physics © 2016.]

The rapid growth of the human cortex during development is accompanied by the folding of the brain into a highly convoluted structure. Most studies have been focusing on the genetic and cellular regulation of cortical growth, but Prof. L. Mahadevan and colleagues from SEAS, Finland and France have provided the first experimental evidence of the theory of differential growth and demonstrated that physical forces — not just biochemical processes alone — play a critical role in neurodevelopment. Their findings could have far-reaching clinical consequences for diagnosing, treating and preventing a wide variety of neurological disorders.

Read the press release on phys.org, "3-D printing confirms physical model of brain folds," the article by Ellen Kuhl, "Biophysics: Unfolding the brain," Nature Physics (2016) doi:10.1038/nphys3641, and the original research paper, T. Tallinen, J.Y. Chung, F. Rousseau, N. Girard, J. Lefèvre & L. Mahadevan, "On the growth and form of cortical convolutions," Nature Physics (2016) doi:10.1038/nphys3632