Michael M. Desai
Natural selection and other evolutionary forces leave characteristic signatures in the genetic variation within populations. Our group uses a combination of theoretical and experimental approaches to study how this genetic variation is created and maintained, and to develop methods to infer the evolutionary history of populations from the variation observed in sequence data. Our focus is primarily on the dynamics and population genetics of natural selection in asexual populations such as microbes and viruses, which are often dominated by the random fluctuations in when and where rare mutational events occur. We are developing new approaches to population genetic theory to better understand the structure of genetic variation in these populations. To complement this theoretical work, we have developed high-throughput techniques which allow us to directly observe the evolution of thousands of experimental budding yeast populations simultaneously, tracking changes in fitness and other phenotypic characteristics and correlating these with the evolution of genetic variation within and between populations.
Faculty Assistant: Jenn Thomson
Cambridge, MA 02138